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Figure_2

Ex vivo experiments

Everted gut sac assay

Schermata 2011-03-08 a 10.43.01

Ex vivo experiments

Organ Bath experiment

DSCF8836

Metabolic stability study

Metabolic stability studies of in vitro

Transient or stable transfection

Transient or stable transfection

Transient or stable cell lines transfection

DSCF8838
DSCF8832

Biochemical pathway evaluation

Cellular Toxicity (ATP assay)

Schermata 2011-03-08 a 11.05.27

Biochemical pathway evaluation

Cellular Toxicity (LDH assay)

Schermata 2011-03-08 a 11.02.47

Biochemical pathway evaluation

Cellular Toxicity (MTT assay)

DSCF8846

Biochemical pathway evaluation

Efflux pump inhibition (ATPase activity)

Schermata 2011-03-08 a 11.07.52

Biochemical pathway evaluation

P-glycoprotein Inhibition (Calcein-AM assay)

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