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Nicola A. Colabufo

Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding.
Tardia P, Stefanachi A, Niso M, Stolfa DA, Mangiatordi GF, Alberga D, Nicolotti O, Lattanzi G, Carotti A, Leonetti F, Perrone R, Berardi F, Azzariti A, Colabufo NA, Cellamare S.
J Med Chem. 2014 Aug 14;57(15):6403-18.
[http://www.ncbi.nlm.nih.gov/pubmed/25093931]

ABC transporters in CSCs membranes as a novel target for treating tumor relapse.
Zinzi L, Contino M, Cantore M, Capparelli E, Leopoldo M, Colabufo NA.
Front Pharmacol. 2014 Jul 10;5:163.
[http://www.ncbi.nlm.nih.gov/pubmed/25071581]

miRNAs for the detection of multidrug resistance: overview and perspectives.
Gisel A, Valvano M, El Idrissi IG, Nardulli P, Azzariti A, Carrieri A, Contino M, Colabufo NA.
Molecules. 2014 Apr 30;19(5):5611-23.
[http://www.ncbi.nlm.nih.gov/pubmed/24786846]

Small and Innovative Molecules as New Strategy to Revert MDR.
Zinzi L, Capparelli E, Cantore M, Contino M, Leopoldo M, Colabufo NA.
Front Oncol. 2014 Jan 21;4:2.
[http://www.ncbi.nlm.nih.gov/pubmed/24478983]

(99m)Tc(N)-DBODC(5), a potential radiolabeled probe for SPECT of multidrug resistance: in vitro study.
Bolzati C, Carta D, Gandin V, Marzano C, Morellato N, Salvarese N, Cantore M, Colabufo NA.
J Biol Inorg Chem. 2013 Jun;18(5):523-38.
[http://www.ncbi.nlm.nih.gov/pubmed/23543234]

Marcello Leopoldo

Synthesis, radiolabeling and in vivo evaluation of [11C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor.
Hansen HD, Lacivita E, Di Pilato P, Herth MM, Lehel S, Ettrup A, Andersen VL, Dyssegaard A, De Giorgio P, Perrone R, Berardi F, Colabufo NA, Niso M, Knudsen GM, Leopoldo M.
Eur J Med Chem. 2014 May 22;79:152-63.
[http://www.ncbi.nlm.nih.gov/pubmed/24732791]

Pharmacological stimulation of the brain serotonin receptor 7 as a novel therapeutic approach for rett syndrome.
De Filippis B, Nativio P, Fabbri A, Ricceri L, Adriani W, Lacivita E, Leopoldo M, Passarelli F, Fuso A, Laviola G.
Neuropsychopharmacology. 2014 Oct;39(11):2506-18.
[http://www.ncbi.nlm.nih.gov/pubmed/24923983]

Activation of 5-HT7 serotonin receptors reverses metabotropic glutamate receptor-mediated synaptic plasticity in wild-type and Fmr1 knockout mice, a model of Fragile X syndrome.
Costa L, Spatuzza M, D’Antoni S, Bonaccorso CM, Trovato C, Musumeci SA, Leopoldo M, Lacivita E, Catania MV, Ciranna L.
Biol Psychiatry. 2012 Dec 1;72(11):924-33.
[http://www.ncbi.nlm.nih.gov/pubmed/22817866]

Serotonin 5-HT7 receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disorders.
Leopoldo M, Lacivita E, Berardi F, Perrone R, Hedlund PB.
Pharmacol Ther. 2011 Feb;129(2):120-48.
[http://www.ncbi.nlm.nih.gov/pubmed/20923682]

LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptor.
Hedlund PB, Leopoldo M, Caccia S, Sarkisyan G, Fracasso C, Martelli G, Lacivita E, Berardi F, Perrone R.
Neurosci Lett. 2010 Aug 30;481(1):12-6.
[http://www.ncbi.nlm.nih.gov/pubmed/20600619]

Roberto Perrone

PET radiotracers for imaging P-glycoprotein: the challenge for early diagnosis in AD.
Leopoldo M, Contino M, Berardi F, Perrone R, Colabufo NA.
ChemMedChem. 2014 Jan;9(1):38-42.
[http://www.ncbi.nlm.nih.gov/pubmed/24174335]

Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview.
Di Pilato P, Niso M, Adriani W, Romano E, Travaglini D, Berardi F, Colabufo NA, Perrone R, Laviola G, Lacivita E, Leopoldo M.
Rev Neurosci. 2014;25(3):401-15.
[http://www.ncbi.nlm.nih.gov/pubmed/24622785]

Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments.
Contino M, Zinzi L, Cantore M, Perrone MG, Leopoldo M, Berardi F, Perrone R, Colabufo NA.
Bioorg Med Chem Lett. 2013 Jul 1;23(13):3728-31.
[http://www.ncbi.nlm.nih.gov/pubmed/23726026]

Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters.
Colabufo NA, Contino M, Cantore M, Capparelli E, Perrone MG, Cassano G, Gasparre G, Leopoldo M, Berardi F, Perrone R.
Bioorg Med Chem. 2013 Mar 1;21(5):1324-32.
[http://www.ncbi.nlm.nih.gov/pubmed/23347803]

Activatable fluorescent probes: a new concept in optical molecular imaging.
Lacivita E, Leopoldo M, Berardi F, Colabufo NA, Perrone R.
Curr Med Chem. 2012;19(28):4731-41.
[http://www.ncbi.nlm.nih.gov/pubmed/22873661]

Francesco Berardi

Novel derivatives of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with improved fluorescent and σ receptors binding properties.
Abate C, Niso M, Marottoli R, Riganti C, Ghigo D, Ferorelli S, Ossato G, Perrone R, Lacivita E, Lamb DC, Berardi F.
J Med Chem. 2014 Apr 24;57(8):3314-23.
[http://www.ncbi.nlm.nih.gov/pubmed/24697311]

Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: hints for collateral sensitivity.
Niso M, Abate C, Contino M, Ferorelli S, Azzariti A, Perrone R, Colabufo NA, Berardi F.
ChemMedChem. 2013 Dec;8(12):2026-35.
[http://www.ncbi.nlm.nih.gov/pubmed/24106081]

Classes of sigma2 (σ2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity.
Abate C, Perrone R, Berardi F.
Curr Pharm Des. 2012;18(7):938-49.
[http://www.ncbi.nlm.nih.gov/pubmed/22288411]

Fluorescent derivatives of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a tool for uptake and cellular localization studies in pancreatic tumor cells.
Abate C, Hornick JR, Spitzer D, Hawkins WG, Niso M, Perrone R, Berardi F.
J Med Chem. 2011 Aug 25;54(16):5858-67.
[http://www.ncbi.nlm.nih.gov/pubmed/21744858]

Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28).
Berardi F, Abate C, Ferorelli S, Uricchio V, Colabufo NA, Niso M, Perrone R.
J Med Chem. 2009 Dec 10;52(23):7817-28.
[http://www.ncbi.nlm.nih.gov/pubmed/19842660]